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KMID : 0356619960110020247
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Journal of Korean Society of Endocrinology
1996 Volume.11 No. 2 p.247 ~ p.252
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Diffuse Nesidioblastosis of the Pancreas in Adult with Persistent Hyperinsulinemic Hypoglycemia
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Abstract
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Nesidioblastosis is a term that describes multifocal hyperplasia of all pancreatic cell components and is characterized primarily by their disorganization and proliferation throughout the entire pancreas. Adult onset nesidioblastosis is an extremely rare entity associated with hypersecretion of insulin. The authors have recently experienced a case of nesidioblastosis in an adult.
A 41-yaer old man was admitted due to intermittent hypoglycemic symptoms, that had been relieved by carbohydrate ingestion. Hyperinsulinemic hypoglycemia was documented during prolonged fast. Under the presumptive diagnosis of insulinoma, abdominal CT, celiac angiogram and percutaneous transhepatic portal venous sampling were done but we could not find any definitive mass. Eight-five percent of the pancreas was removed. Pathologic examination of the resected pancreas revealed irregularly sized islets and scattering of small endocrine cell clusters throughout the acinar tissue and ductuloinsular complex(J Kor Soc Endocrinol 11:247~253, 1996).
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